It’s a TRAPP! Arabidopsis Transport Protein Particle (TRAPP) Complexes Contain a Novel Plant-Specific Subunit
نویسندگان
چکیده
منابع مشابه
The structure of the TRAPP subunit TPC6 suggests a model for a TRAPP subcomplex.
The TRAPP (transport protein particle) complexes are tethering complexes that have an important role at the different steps of vesicle transport. Recently, the crystal structures of the TRAPP subunits SEDL and BET3 have been determined, and we present here the 1.7 Angstroms crystal structure of human TPC6, a third TRAPP subunit. The protein adopts an alpha/beta-plait topology and forms a dimer....
متن کاملVesicle Transport: Springing the TRAPP
When a coated transport vesicle docks with its target membrane, the coat proteins and docking machinery must be released before the membranes can fuse. A recent paper shows how this disassembly is triggered at precisely the right time.
متن کاملTrs33-Containing TRAPP IV: A Novel Autophagy-Specific Ypt1 GEF.
Ypt/Rab GTPases, key regulators of intracellular trafficking pathways, are activated by guanine-nucleotide exchange factors (GEFs). Here, we identify a novel GEF complex, TRAPP IV, which regulates Ypt1-mediated autophagy. In the yeast Saccharomyces cerevisiae, Ypt1 GTPase is required for the initiation of secretion and autophagy, suggesting that it regulates these two distinct pathways. However...
متن کاملTRAPP Complexes in Secretion and Autophagy
TRAPP is a highly conserved modular multi-subunit protein complex. Originally identified as a "transport protein particle" with a role in endoplasmic reticulum-to-Golgi transport, its multiple subunits and their conservation from yeast to humans were characterized in the late 1990s. TRAPP attracted attention when it was shown to act as a Ypt/Rab GTPase nucleotide exchanger, GEF, in the 2000s. C...
متن کاملResponse to Kessell and Trapp
Sir, Williamson and colleagues’ description of their successful use of rocuronium for rapid sequence induction with subsequent reversal using sugammadex in an obstetric cohort is interesting for a number of reasons. Firstly, the paper states that the mean duration of action of rocuronium at a dose of 1.2 mg/kg is 60–73 min and that this ‘is significantly longer than most obstetric procedures’. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Plant Cell
سال: 2020
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.20.00375